Pharmacology of Progestogens
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چکیده
منابع مشابه
The effect of oral contraceptive steroids on bile secretion and bilirubin Tm in rats.
1. The effect of oestrogens and progestogens and their 17alpha-ethinyl derivatives on bile flow, maximum rate of bilirubin secretion, serum and liver bilirubin has been studied.2. Both 17alpha-ethinyl substituted oestrogens and progestogens greatly reduced the basal bile flow. The parent compounds, oestradiol-17beta and 19-nortestosterone had little or no effect.3. A much larger dose of progest...
متن کاملFree estrogens and progestogens in benign prostatic hypertrophy.
Studies on the presence of free estrogens and progestogens in human prostates clearly differentiate the benign hypertrophied prostates from normals. Both contained 17 alpha-hydroxypregnenolone 5 beta-pregnane-3, 20-dione, 5 alpha-pregnane-3, 20-dione and 16 alpha-hydroxyestrone. However, presence of 11 alpha-hydroxyprogesterone 20 beta-hydroxypregnenolone, pregnenolone, 17 alpha-hydroxyprogeste...
متن کاملComparative pharmacology of newer progestogens.
The newer progestogens desogestrel, norgestimate, gestodene, dienogest and nomegestrol share the common property of having weak or no androgenic effects, but there is great variation between agents in their pharmacokinetic properties and hormonal activities. Both desogestrel (acting as 3-keto-desogestrel) and norgestimate (acting mainly through levonorgestrel) are prodrugs. While nomegestrol is...
متن کاملPharmacology of estrogens and progestogens: influence of different routes of administration.
This review comprises the pharmacokinetics and pharmacodynamics of natural and synthetic estrogens and progestogens used in contraception and therapy, with special consideration of hormone replacement therapy. The paper describes the mechanisms of action, the relation between structure and hormonal activity, differences in hormonal pattern and potency, peculiarities in the properties of certain...
متن کاملProgestogens and membrane-initiated effects on the proliferation of human breast cancer cells.
OBJECTIVES Evidence is accumulating that progestogens may play a crucial role in the development of breast cancer under contraception and hormone therapy in reproductive and menopausal women. Progesterone receptor membrane component 1 (PGRMC1) expressed in breast cancer may be important in tumorigenesis and thus may increase breast cancer risk. The aim of this project was to investigate the inf...
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